PTC-209 (hydrobroMide)
PTC-209 HBr
CAS: 1217022-63-3
Molecular Formula: C17H14Br3N5OS
PTC-209 (hydrobroMide) - Names and Identifiers
PTC-209 (hydrobroMide) - Physico-chemical Properties
| Molecular Formula | C17H14Br3N5OS |
| Molar Mass | 576.10296 |
| Storage Condition | 2-8℃ |
| In vitro study | PTC-209 inhibition of UTR-mediated reporter gene expression and endogenous BMI-1 expression in human colorectal HCT116 and human fibrosarcoma HT1080 tumor cells. PTC-209 reduced the growth of colorectal cancer tumor cells in a BMI-1-dependent manner. In addition, PTC-209 of colorectal cancer-initiating cells (CICs) were damaged by irreversible growth inhibition. |
| In vivo study | In primary human colon cancer xenograft, human colon cancer cell line LIM1215 or HCT116 xenograft mice, PTC-209 (60 mg/kg/day, subcutaneous injection) effectively inhibited BMI-1 production in tumor tissue, and to stop the growth of the tumor has been generated. PTC-209 will also reduce the frequency of functional colorectal cancer CICs in vivo. |
PTC-209 (hydrobroMide) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.736 ml | 8.679 ml | 17.358 ml |
| 5 mM | 0.347 ml | 1.736 ml | 3.472 ml |
| 10 mM | 0.174 ml | 0.868 ml | 1.736 ml |
| 5 mM | 0.035 ml | 0.174 ml | 0.347 ml |
Last Update：2024-01-02 23:10:35
PTC-209 (hydrobroMide) - Reference Information
| Biological activity | PTC-209 HBr is a PTC-209 hydrobromide, which is a potent selective BMI-1 inhibitor with an IC50 of 0.5 μM, which can irreversibly reduce cancer initiation cells (CICs). |
| In vitro study | PTC-209 inhibit UTR-mediated reporter gene expression and endogenous BMI-1 expression in human colorectal HCT116 and human fibrosarcoma HT1080 tumor cells. PTC-209 reduce the growth of colorectal cancer tumor cells in a BMI-1-dependent manner. In addition, PTC-209 damage colorectal cancer initiation cells (CICs) through irreversible growth inhibition. |
| in vivo study | in mice xenograft of primary human colon cancer, human colon cancer cell line LIM1215 or HCT116 xenograft, PTC-209 (60 mg/kg/day, subcutaneous injection) effectively inhibits the production of BMI-1 in tumor tissue and stops the growth of the produced tumor. PTC-209 will also reduce the frequency of functional colorectal cancer CICs in vivo. |
| features | BMI-1-selective inhibitor, targeting the BMI-1 self-replication mechanism. |
Last Update：2024-04-09 21:04:16
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CAS: 1217022-63-3
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CAS: 1217022-63-3
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View History
PTC-209 (hydrobroMide)
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Methyl (S)-(1-((4-(3-iodo-1-isopropyl-1H-pyrazol-4-yl)pyrimi...
Cucumber, ext.
CHOLESTERYL HEMISUCCINATE MORPHOLINE)
Clarithromycin Impurity 1(Clarithromycin EP Impurity D)
(CYS(ET)2,7)-ALPHA-CALCITONIN GENE-RELATED PEPTIDE (HUMAN)
1-CYCLOPROPYLPIPERAZINE
magnesium aluminosilicate (cordierite)
2-羟基-4-[[[[(4-甲苯基)磺酰基]氧]氨基]苯甲酸乙酰]
DODECANE DIBROMIDE